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Search Results for " Nitric oxide synthases "

ターゲット

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T7474	7-Nitroindazole		NOS
	7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.		NOS
T10107	3-Bromo-7-nitroindazole		NOS
			NOS
T1322	Bendazol	Dibazol,Dibazole	Dopamine Receptor , NO Synthase
	Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.		Dopamine Receptor , NO Synthase
T22724	Dimaprit dihydrochloride		NOS , NO Synthase , Histamine Receptor
	Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.		NOS , NO Synthase , Histamine Receptor
T19853	Dimethoxycurcumin	Veratrylcurcuminoid	Others
	Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.		Others
T15697	L-NMMA acetate	Tilarginine acetate,Methylarginine acetate	NOS
			NOS
T21507	7-Ethoxyresorufin	Resorufin ethyl ether	P450 , NO Synthase
	7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.		P450 , NO Synthase
T21700	NOS-IN-1	2-Imino-4-methylpiperidine (acetate)	NOS
	NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectiv...		NOS
T7461	2,4-Diamino-6-hydroxypyrimidine	DAHP	Reactive Oxygen Species , NO Synthase
	2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis		Reactive Oxygen Species , NO Synthase
T2334	Avanafil	TA1790	PDE
	Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.		PDE
T3491	1400W dihydrochloride	1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine	NOS , NO Synthase
	1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS).		NOS , NO Synthase
T12808	S-Nitroso-N-acetyl-DL-penicillamine	SNAP	NO Synthase
	S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .		NO Synthase
T19916	TRIM	1-(2-Trifluoromethylphenyl)imidazole	NOS
	TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS.		NOS
T1479	Isosorbide dinitrate	Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others , NO Synthase
	Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.		Others , NO Synthase
T7206L	2-Iminobiotin hydrobromide	Guanidinobiotin	NOS , NO Synthase
	2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse i...		NOS , NO Synthase
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T1102	Mifepristone	C-1073,RU486,RU 38486	Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , NO Synthase , Autophagy
	Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T22419	S-Methylisothiourea sulfate	(S)-Methylisothiourea sulfate	NOS , NO Synthase , HSV
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].		NOS , NO Synthase , HSV
T6888	Methylene Blue	methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9	Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
	Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T3211	Midostaurin	N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251	Others , PKC
	PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...		Others , PKC
T0006	Methylene Blue trihydrate	Methylthionine chloride,Basic blue 9,Methylene Blue	Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
	Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T6570	L-NAME hydrochloride	L-NAME HCl,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride	NOS , NO Synthase
	L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.		NOS , NO Synthase
T0358	Aminoguanidine hydrochloride	Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,Guanyl hydrazine,Pimagedine	NOS , NO Synthase
	Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.		NOS , NO Synthase
T9537	N'-Nitro-D-arginine	N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid	Others
	N'-Nitro-D-arginine (N'-Nitro-D-arginine) is a Building Block.		Others
T7206	2-Iminobiotin	2-IMINOBIOTIN HYDROBROMIDE,Guanidinobiotin	NOS , NO Synthase
	2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat n...		NOS , NO Synthase
T78229	Aminoguanidine hemisulfate		Reactive Oxygen Species
	Aminoguanidine hemisulfate, an inhibitor of nitric oxide synthases (NOS) and reactive oxygen species (ROS), effectively suppresses ANE-induced ROS production in vitro and is utilized in cancer research [1].		Reactive Oxygen Species
T21366	Sapropterin free base	BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin
	Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatoni...

Compounds

3-Bromo-7-nitroindazole

Synonym: Dibazol,Dibazole

Target: Dopamine Receptor, NO Synthase

Dimaprit dihydrochloride

T22724

Synonym:

Target: NOS, NO Synthase, Histamine Receptor

Dimethoxycurcumin

T19853

Synonym: Veratrylcurcuminoid

Target: Others

L-NMMA acetate

T15697

Synonym: Tilarginine acetate,Methylarginine acetate

Target: NOS

7-Ethoxyresorufin

T21507

Synonym: Resorufin ethyl ether

Target: P450, NO Synthase

NOS-IN-1

T21700

Synonym: 2-Imino-4-methylpiperidine (acetate)

Target: NOS

2,4-Diamino-6-hydroxypyrimidine

T7461

Synonym: DAHP

Target: Reactive Oxygen Species, NO Synthase

1400W dihydrochloride

T3491

Synonym: 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine

Target: NOS, NO Synthase

S-Nitroso-N-acetyl-DL-penicillamine

Synonym: 1-(2-Trifluoromethylphenyl)imidazole

Target: NOS

Isosorbide dinitrate

T1479

Synonym: Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

2-Iminobiotin hydrobromide

T7206L

Synonym: Guanidinobiotin

Target: NOS, NO Synthase

PRE-084 hydrochloride

T3198L

Synonym:

Target: Sigma receptor

Mifepristone

T1102

Synonym: C-1073,RU486,RU 38486

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy

S-Methylisothiourea sulfate

T22419

Synonym: (S)-Methylisothiourea sulfate

Target: NOS, NO Synthase, HSV

Methylene Blue

T6888

Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Midostaurin

T3211

Synonym: N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251

Target: Others, PKC

Methylene Blue trihydrate

T0006

Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

L-NAME hydrochloride

T6570

Synonym: L-NAME HCl,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride

Target: NOS, NO Synthase

Aminoguanidine hydrochloride

T0358

Synonym: Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,Guanyl hydrazine,Pimagedine

Target: NOS, NO Synthase

N'-Nitro-D-arginine

T9537

Synonym: N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid

Target: Others

2-Iminobiotin

T7206

Synonym: 2-IMINOBIOTIN HYDROBROMIDE,Guanidinobiotin

Target: NOS, NO Synthase

Aminoguanidine hemisulfate

T78229

Synonym:

Target: Reactive Oxygen Species

Sapropterin free base

T21366

Synonym: BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin

Target:

カタログ番号	製品名	別名	ターゲット
TQ0301	Kuwanon A		NO Synthase
			NO Synthase
T6S2023	Harpagoside		Others , COX , NO Synthase
	1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression...		Others , COX , NO Synthase
T2S0765	Epibetulinic acid		NO Synthase , Prostaglandin Receptor
	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.		NO Synthase , Prostaglandin Receptor
T6S1665	Irisflorentin		Others , NO Synthase
	1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechan...		Others , NO Synthase
T7682	Asymmetric dimethylarginine		Endogenous Metabolite , NO Synthase , NOD
	Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)		Endogenous Metabolite , NO Synthase , NOD
T3847	Asperuloside	Asperulosid	Others , NO Synthase
	Asperuloside (Asperulosid) has anti-inflammatory activity.		Others , NO Synthase
T5838	L-Canavanine sulfate		NO Synthase , NOD
	L-Canavanine sulfate is a selective inducible NO synthase inhibitor.		NO Synthase , NOD
T5S0285	Cistanoside A		Others
	1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat...		Others
T2791	Pectolinarin		Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin
	Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
T7597	6-Biopterin	L-Biopterin	Endogenous Metabolite , NO Synthase , NOD
	6-Biopterin (L-Biopterin) is a natural product,is a NO synthase cofactor.		Endogenous Metabolite , NO Synthase , NOD
T4808	Agmatine sulfate	Agmatine sulfate salt	Endogenous Metabolite , NO Synthase , Imidazoline Receptor
	Agmatine sulfate (Agmatine sulfate salt) is a bioactive metabolite of the arginine amino acid. It exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide sy...		Endogenous Metabolite , NO Synthase , Imidazoline Receptor
TN2139	Regaloside B		NOS , COX , NO Synthase
	Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2).		NOS , COX , NO Synthase
T2980	Chondroitin sulfate	Chonsurid,Chondroitin polysulfate	MMP , Others , Endogenous Metabolite , NO Synthase
	Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition		MMP , Others , Endogenous Metabolite , NO Synthase
T2S2335	Dehydroevodiamine	DHED	Others , NF-κB , COX , PGE Synthase , NO Synthase
	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...		Others , NF-κB , COX , PGE Synthase , NO Synthase
T1310	2-Thiouracil	Thiouracil,Deracil	Thyroid hormone receptor(THR) , NO Synthase
	2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.		Thyroid hormone receptor(THR) , NO Synthase
T3S0364	L-Arginine	L-Arg,(S)-(+)-Arginine	IL Receptor , Endogenous Metabolite , NO Synthase
	1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate...		IL Receptor , Endogenous Metabolite , NO Synthase
T7030	Anemarsaponin B		p38 MAPK , NF-κB , MEK , COX , NO Synthase
	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c...		p38 MAPK , NF-κB , MEK , COX , NO Synthase
TN1373	α-Humulene	Alpha-caryophyllene	TNF , NOS , COX
	α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production an...		TNF , NOS , COX
T7786	Tryptanthrin		DNA gyrase
	Tryptanthrin is a natural DNA gyrase inhibitor.		DNA gyrase
T5681	ETHYL CAFFEATE	ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB , COX , PGE Synthase , NO Synthase
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...		NF-κB , COX , PGE Synthase , NO Synthase
T5684	Ethyl 3,4-dihydroxybenzoate		Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T3918	Ginsenoside Rb3	Gypenoside IV	NF-κB , COX , NO Synthase
	Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA.		NF-κB , COX , NO Synthase
T3805	Prim-O-glucosylcimifugin	Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF , COX , JAK , NO Synthase
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.		TNF , COX , JAK , NO Synthase
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T3811	Ginsenoside C-K	Ginsenoside compound K,Ginsenoside K	P450 , cell cycle arrest , COX , NO Synthase
	Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.		P450 , cell cycle arrest , COX , NO Synthase
T5S0754	Isoquercetin	3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside	NF-κB , Wnt/beta-catenin , NO Synthase
	1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ...		NF-κB , Wnt/beta-catenin , NO Synthase
T2758	Madecassic acid	6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose	Others , TNF , COX , NO Synthase , Interleukin
	Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.		Others , TNF , COX , NO Synthase , Interleukin
T3S0401	Piceatannol 3'-O-glucoside	Piceatannol 3-glycoside,Quzhaqigan	Arginase , NO Synthase
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.		Arginase , NO Synthase
T0670	L-Arginine hydrochloride	(S)-(+)-Arginine hydrochloride,L-Arginine HCl (L-Arg),L-arginine monohydrochloride	Amino Acids and Derivatives , Endogenous Metabolite , NO Synthase
	L-Arginine hydrochloride is a nitrogen donor for synthesis of nitric oxide.
TN1102	Physalin L		Others , NO Synthase
	Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.		Others , NO Synthase
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	NOS , NO Synthase , Prostaglandin Receptor
	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.		NOS , NO Synthase , Prostaglandin Receptor
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K